The Louisiana region was settled by Indians in prehistoric times, at least as early as 6,000 years ago. At the time of European exploration in the 16th century, there were more than 10,000 Indians in Louisiana. Tribes of the Muskhogean language family occupied the east-central and southeast region, Tunican tribes lived along the coast and in the northeast, and tribes of the Caddoan group inhabited the north and northwest. Generally these Indians lived in permanent villages and depended upon agriculture for their subsistence.
| Important dates in Louisiana | |
| 1541 | Hernando de Soto led a group of Spanish conquistadors (conquerors) into the lower Mississippi River area. |
| 1682 | Rene-Robert Cavelier, Sieur de La Salle, reached the mouth of the Mississippi River. He claimed for France all the land drained by the Mississippi and its tributary river systems. |
| 1699 | Pierre Le Moyne, Sieur d’Iberville, reclaimed the area for France. France had earlier abandoned it. |
| 1714 | Louis Juchereau de St. Denis founded Natchitoches, the first permanent town in Louisiana. |
| 1718 | Jean-Baptiste Le Moyne, Sieur de Bienville, founded New Orleans. |
| 1762 | France ceded Louisiana to Spain. |
| 1795 | Etienne de Bore successfully began granulating sugar on his New Orleans plantation. |
| 1800 | Spain ceded Louisiana back to France. |
| 1803 | The U.S. purchased Louisiana from France. |
| 1812 | Louisiana became the 18th state on April 30. |
| 1815 | During the War of 1812, Andrew Jackson and his small force defeated the British in the Battle of New Orleans. Neither side was aware that the war had ended two weeks earlier. |
| 1861 | Louisiana seceded from the Union. |
| 1862 | Union troops captured New Orleans during the American Civil War (1861-1865) and held the city throughout the war. |
| 1868 | Louisiana was readmitted to the Union. |
| 1901 | Oil was discovered near Jennings and White Castle. |
| 1916 | The Monroe natural gas field was opened. |
| 1928 | Huey P. Long was elected governor. |
| 1935 | Long, at the time a U.S. senator, was assassinated. |
| 1963 | The Mississippi River-Gulf Outlet, a short cut for shippers between New Orleans and the sea, opened. |
| 1975 | The new state Constitution went into effect. |
| 1979 | David C. Treen became the first Republican to be elected governor of Louisiana since the 1870’s. |
| 1990 | Louisiana voters approved a state lottery. |
| 2003 | Kathleen B. Blanco became the first woman to be elected governor of Louisiana. |
