Three of the most ancient peoples of the Americas are named for sites in New Mexico where relics of them were first found. These are the Folsom, Clovis, and Sandia peoples of 10,000 to 12,000 years ago. Pueblos (villages) such as Acoma are among the oldest continuously occupied sites in the Americas, dating to hundreds of years before Columbus. After the Pueblo Indians other groups arrived in the area—the Navajos, the Apaches, the Utes, and, in the 18th century, the Comanches.
| Important dates in New Mexico | |
| 1540-1542 | Francisco Vásquez de Coronado explored New Mexico. |
| 1598 | Juan de Onate founded the first permanent Spanish colony, at San Juan. |
| 1609 or 1610 | Governor Pedro de Peralta established Santa Fe. |
| 1680 | The Pueblo Indians revolted and drove the Spaniards out of northern New Mexico. |
| 1692 | Diego de Vargas reconquered New Mexico for Spain. |
| 1706 | Francisco Cuervo y Valdes founded Albuquerque. |
| 1821 | Mexico won its independence from Spain, and New Mexico became a province of Mexico. William Becknell opened the Santa Fe Trail. |
| 1846 | General Stephen W. Kearny took control of New Mexico during the Mexican War. |
| 1848 | Mexico ceded New Mexico to the United States. |
| 1850 | Congress created the Territory of New Mexico. |
| 1853 | New Mexico acquired part of the Gila Valley. |
| 1862-1864 | Colonel Kit Carson defeated the Mescalero Apache and Navajo Indians. |
| 1876 | Cattlemen began the Lincoln County War. |
| 1886 | The surrender of Geronimo ended the Apache Wars. |
| 1912 | New Mexico became the 47th state on January 6. |
| 1916 | Mexican bandits raided Columbus. |
| 1922 | Geologists discovered oil in the southeastern and northwestern regions of New Mexico. |
| 1945 | The first atomic bomb was exploded at Trinity Site near Alamogordo. |
| 1950 | Paddy Martinez, a Navajo Indian, found uranium in the northwest region. |
| 1970's | Completion of the San Juan-Chama project brought water to north-central New Mexico. |
| 1998 | New Mexico celebrated the 400th anniversary of the founding of the colony at San Juan. |

