Archeological evidence indicates that North Carolina was inhabited by prehistoric Indians at least as early as 10,000 B.C. The area was continuously occupied through the centuries by various Indian peoples. When Europeans arrived to settle in the late 16th century, there were some 30,000 to 35,000 Indians in North Carolina. The most important tribes were the Hatteras, Chowanoc, Tuscarora, Catawba, and Cherokee.
| Important dates in North Carolina | |
| 1524 | Giovanni da Verrazzano, a Florentine explorer sailing for France, visited the North Carolina coast. |
| 1585 | The English established at Roanoke Island their first colony in what is now the United States. |
| 1629 | King Charles I of England granted Carolana to Sir Robert Heath. |
| 1650? | The first permanent settlers came to the Albemarle region from Virginia. |
| 1663 | King Charles II granted the Carolina colony to eight lords proprietors. |
| 1664 | North Carolina's first permanent government was established in Albemarle County. |
| 1711 | The Tuscarora Indians attacked settlements between the Neuse and Pamlico rivers. The colonists defeated the Indians in 1713. |
| 1729 | North Carolina came under direct royal rule. |
| 1765 | Colonists in North Carolina began to resist enforcement of the British Stamp Act and other tax laws. |
| 1774 | North Carolina sent delegates to the First Continental Congress in Philadelphia. |
| 1776 | The Whigs defeated the Tories at Moore's Creek Bridge. North Carolina adopted its first constitution. |
| 1781 | British forces withdrew from North Carolina and surrendered in Virginia. |
| 1789 | North Carolina ratified the Constitution and became the 12th state on November 21. |
| 1835 | Constitutional changes gave greater representation to the counties of western North Carolina. |
| 1861 | North Carolina seceded from the Union. |
| 1865 | General Joseph E. Johnston surrendered to General William T. Sherman near Durham. |
| 1868 | North Carolina was readmitted to the Union. |
| 1901 | Governor Charles B. Aycock began a campaign to improve North Carolina public schools. |
| 1903 | The Wright brothers made the first successful powered airplane flight near Kitty Hawk. |
| 1915 | The state legislature set up a highway commission. |
| 1933 | The state took over the support of public schools. |
| 1949 | The people approved a large bond issue for road and public-school construction. |
| 1950 | Great industrial expansion began. |
| 1959 | The North Carolina Research Triangle Park, operated by three of the state's universities to serve industry, opened. |
| 1960 | Four black students launched the sit-in movement at a lunch counter in Greensboro. |
| 1971 | A new state Constitution went into effect. |
| 1972 | James E. Holshouser, Jr., became the first Republican to be elected governor of North Carolina since 1896. |
| 1989 | North Carolina marked the bicentennial of its statehood. |


