In prehistoric times Ohio was the home of Indians known as Mound Builders. When the French first settled in Canada in the early 17th century, the Erie Indians were living south of Lake Erie, but in mid-century they were conquered and dispersed by the Iroquois. The Ohio River was discovered by the French, probably by La Salle on his trip of 1669.
| Important dates in Ohio | |
| c. 1670 | The French explorer Rene-Robert Cavelier, Sieur de La Salle, probably was the first white man to reach the Ohio region. |
| 1747 | The Ohio Company of Virginia was organized to colonize the Ohio River Valley. |
| 1763 | France surrendered its claim to the Ohio region to Britain. |
| 1787 | The Northwest Territory was established. |
| 1788 | The first permanent white settlement in Ohio was established in Marietta. |
| 1795 | Indian wars in the Ohio region ended with the Treaty of Greenville. |
| 1800 | The Division Act divided the Northwest Territory into two parts, and Chillicothe became the capital of the new Northwest Territory. |
| 1803 | Ohio became the 17th state on March 1. |
| 1813 | Commodore Oliver H. Perry's fleet defeated the British in the Battle of Lake Erie. |
| 1832 | The Ohio and Erie Canal was completed. |
| 1836 | The Ohio-Michigan boundary dispute was settled. |
| 1845 | The Miami and Erie Canal was completed. |
| 1870 | Benjamin F. Goodrich began the manufacture of rubber goods in Akron. |
| 1914 | Ohio passed the Conservancy Act after floods in 1913. |
| 1922 | The Miami River Valley flood-control project was finished. |
| 1938 | The flood-control project in the Muskingum River Valley was completed. |
| 1955 | The Ohio Turnpike was opened to traffic. |
| 1959 | Terms of the governor and other high state officials were increased from two years to four. |
| 1967 | Ohio voters approved a plan for reapportionment of the state legislature. |
| 1971 | Ohio adopted an income tax. |
| 1993 | Ohio voters approved the sale of $200 million worth of bonds to finance improvements and expansion in the state's parks and other recreation areas. |
| 2003 | Ohio celebrated its bicentennial. |
