Wayne, Anthony (1745–1796), a United States army officer. Wayne was an able commander in the Revolutionary War and, after the war, against Indians in the Northwest Territory. He was known as "Mad Anthony" because of the boldness of his tactics and because of his courage, at times bordering on recklessness, in battle. Fort Wayne, Indiana, site of a fort he established in 1794, is named for him.

Wayne was born in Chester County, Pennsylvania, into a prominent family. He worked as a surveyor and then ran his family's farm and tannery. At the start of the Revolutionary War, he was commissioned a colonel and took part in the expedition to Canada. Wayne then commanded Fort Ticonderoga, 1776–77, and was promoted to brigadier general. He distinguished himself by bravery at the battles of Brandywine and Germantown. In 1779 he personally led troops storming the fortress of Stony Point on the Hudson River. For this, he received a gold medal and the thanks of Congress.

In the Yorktown campaign (1781), Wayne, with 800 men, was ordered to attack what the American command thought to be a small British force. When Wayne discovered that his troops were opposed by 5,000 British soldiers, he boldly led a charge against their lines and in the resulting confusion withdrew with only minor losses.

After the war, Wayne helped drive hostile Indians out of Georgia. He later settled on a plantation given to him by the state. He represented Georgia in Congress, 1791–92. In 1792 Wayne was made commander of forces sent to the Northwest Territory to fight Indians who had won victories there. He drove the Indians as far as Fallen Timbers, near present-day Toledo, Ohio, and defeated them in 1794. The next year he negotiated the Treaty of Greenville, which ended Indian raids and opened Ohio and much of Indiana to settlement.